Amphipolis (Αμφίπολις, Αμφιπολίτης, Neokhorio; in Turkish Jeni-Keui), a town in Macedonia
on the left or eastern bank of the Strymon, just below its egress from the lake Cercinitis, and about 3 miles from the sea. The Strymon flowed almost round the town, nearly forming a circle, whence itsname Amphi-polis. It was originally called Εννεαοδοί "the Nine Ways," and belonged to the Edonians, a Thracian people. Aristagoras of Miletus first attempted to colonize it, but was cut off with his followers by the Edonians in 497 BC. The Athenians made a next attempt with 10,000 colonists, but they were all destroyed by the Edonians in 465. In 437 the Athenians were more successful, and drove the Edonians out of the "Nine Ways," which was henceforth called Amphipolis. It was one of the most important of the Athenian possessions, being advantageously situated for trade on a navigable river in the midst of a fertile country, and near the gold mines of M. Pangaeus. Hence the indignation of the Athenians when it fell into the hands of Brasidas (424 BC) and of Philip (358 BC). Under the Romans it was a free city, and the capital of Macedonia Prima: the Via Egnatia ran through it. The port of Amphipolis was Eion.

Sources:

Smith, William. "A Classical Dictionary of Biography, Mythology, and Geography". London: John Murray, 1878. p. 45.